Coming to Grips with Obesity

Science is approaching a better understanding of the increasingly prevalent disease; the consequences of succeeding in this quest are great.

Fanning the Flames

Obesity triggers a fatty acid synthesis pathway, which in turn helps drive T cell differentiation and inflammation.

Fat Saps Muscle

The accumulation of fat within skeletal muscle, as happens with obesity, diminishes muscle performance.

Remote Mind Control

Using chemogenetic tools to spur the brain into action

Heady Stuff

New research on how fat influences brain neuronal activity

News & Opinion

Covering the life sciences inside and out

Advances in neuroimaging have improved our understanding of the brain, but the resulting data do little to help judges and juries determine criminal culpability.

Researchers should pay closer attention to the diets they use to study obesity in mice, experts advise.

A type of bariatric surgery eliminates gut-to-brain signals that trigger sugar highs, a mouse study shows.  

image: Genome Digest

Genome Digest


What researchers are learning as they sequence, map, and decode species’ genomes

The Nutshell

Daily News Roundup

New clues from ancient DNA reveal the remarkable effect of agriculture on adaptation in Stone Age humans who lived across Europe.

Bacteria in the intestine produce proteins that stop rodents from eating.

One large provider says the shortfall should clear up by early 2016.

Using the precision gene-editing tool, researchers demonstrate an ability to create large populations of malaria parasite–resistant mosquitoes.

Current Issue

November 2015

Issue Cover: The Obesity Issue

This year’s survey highlights dramatic regional, sector, and gender variations.

Obese people are at higher risk for developing cancer, have worse prognoses once diagnosed, and are often resistant to chemotherapy regimens. The question is, Why?

Low doses of environmental chemicals can make animals gain weight. Whether they do the same to humans is a thorny issue.

Why do some obese people actually experience health benefits?


Video, Slideshows, Infographics

How the foods that make us fattest are not that different from heroin and cocaine

Columbia University researcher Rudy Leibel discusses a study that found benefit in a high-fat diet.

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Featured Comment

But not all diagnostics can be made to have high reliability, specificity, etc. The cure for that ... is not to get rid of the diagnostics, but to require that ... the inherent problems are clearly stated with the test and its results.

- Brian Hanley, FDA: Lab Tests Can Cause Harm
Life Technologies