Battling the Bulge

Weight-loss drugs that target newly characterized obesity-related receptors and pathways could finally offer truly effective fat control.

Weight's the Matter?

The causes and consequences of obesity are more complicated than we thought.

Fat Saps Muscle

The accumulation of fat within skeletal muscle, as happens with obesity, diminishes muscle performance.

Remote Mind Control

Using chemogenetic tools to spur the brain into action

News & Opinion

Covering the life sciences inside and out

image: Cortical Census

Cortical Census


Scientists document the characteristics and connections of mouse neocortical neurons to establish the most detailed microcircuit map to date.

Genetic engineering—once a trigger for federal oversight—is now ushering some modified crops around scrutiny.

Molecular markers could aid researchers’ assessment of patient response to the drug.  

image: Channeling Animals

Channeling Animals


Artists reinterpret structures built by birds, insects, and corals in a new exhibit.

The Nutshell

Daily News Roundup

New mouse interneurons found; epigenetic effects of an antidepressant; defining “high-fat” diets; animal-inspired art  

Turing Pharmaceuticals will soon offer discounts to hospitals for its toxoplasmosis-fighting drug, the company announced, but some say the proposed price reductions are not enough.

A panel of experts advised the US Food and Drug Administration that BioMarin Pharmaceutical has not demonstrated efficacy of its new drug for Duchenne muscular dystrophy.

Domestication may have saved pumpkins, gourds, and squash as seed dispersers like the mastodon went extinct. 

Current Issue

November 2015

Issue Cover: The Obesity Issue

This year’s survey highlights dramatic regional, sector, and gender variations.

Obese people are at higher risk for developing cancer, have worse prognoses once diagnosed, and are often resistant to chemotherapy regimens. The question is, Why?

Low doses of environmental chemicals can make animals gain weight. Whether they do the same to humans is a thorny issue.

Why do some obese people actually experience health benefits?


Video, Slideshows, Infographics

How the foods that make us fattest are not that different from heroin and cocaine

Columbia University researcher Rudy Leibel discusses a study that found benefit in a high-fat diet.

The Marketplace

New Product Press Releases

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Universal Controlled Laboratory Reactor Simplifies Synthesis Scale-up

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VACUU•VIEW and VACUU•VIEW extended Vacuum Gauges

Chromatin Immunoprecipitation (ChIP)-validated antibodies

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Featured Comment

But not all diagnostics can be made to have high reliability, specificity, etc. The cure for that ... is not to get rid of the diagnostics, but to require that ... the inherent problems are clearly stated with the test and its results.

- Brian Hanley, FDA: Lab Tests Can Cause Harm
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