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The Yeast Two-hybrid Assay
How a grant-writing epiphany led to a functional genomics workhorse
Email: Mark Greener - mgreener@the-scientist.com; Jeffrey M Perkel - jperkel@the-scientist.com The Scientist 2005, 19(16):32
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No protein is an island. They're linked by complex networks, and many cellular processes – transcription, translation, mitosis, and motility, to name but a few – are the work of complex macromolecular machines. Researchers keen to figure out how proteins interact were for many years hamstrung by relatively crude, and labor-intensive, analytical tools. Then, in the late-1980s, a new option emerged: the yeast two-hybrid (Y2H) assay.
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