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Maldi
Pioneering ionization technique paved the way for proteomics
Email: Aileen Constans - aconstans@the-scientist.com The Scientist 2005, 19(16):37
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If you hit them, they will fly – that's the basic concept behind MALDI, an ionization technique developed in the late 1980s to enable mass spectrometric analysis of large biomolecules. Despite early tepid reviews, MALDI-TOF (matrix-assisted laser desorption ionization-time of flight) mass spectrometry arguably made large-scale proteomics possible, as the technique can volatilize large biomolecules quickly and efficiently without completely ripping them apart.
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