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How It Works | MALDI-TOF/TOF
The Scientist 2005, 19(16):40
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It's been 20 years since Hillenkamp and Karas developed MALDI. In that time, the soft ionization method, coupled with time-of-flight (TOF) mass spectrometry, has distinguished itself as the enabling technology of proteomics. If you need to identify the proteins in a two-dimensional gel electrophoresis spot, or identify and quantify the relative abundance of thousands of proteins in a cell lysate, take a look at MALDI-TOF.
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