The Scientist : DNA Damage Responses: Cancer and Beyond [10/10/2005]

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by Michael B Kastan

VISION

DNA Damage Responses: Cancer and Beyond

Have we learned enough to design new therapies or prevention approaches?

Email: Michael B Kastan - michael.kastan@stjude.org
The Scientist 2005, 19(19):24

Published

10 October 2005

The composition and sequence of 3 billion bases of DNA serve as a major determinant of our individual physiology. Unfortunately, our DNA is constantly being challenged by agents that arise from either normal metabolism or exposures to natural or artificial products in the environment. Agents from sunlight to chemicals, ionizing radiation, and oxygen radicals can either directly damage bases or break the phosphodiester backbone on which the bases reside.

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