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Comparative Genomics on the Rise
Yeast species comparison reveals annotational power in alignments
Email: Nicole Johnston - njohnston@the-scientist.com The Scientist 2005, 19(11):26
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Simple, fast-growing, and sexually reproducing, yeast have been a stalwart model for generations of geneticists. The first eukaryote sequenced nearly a decade ago, and amenable to high-throughput techniques, they have also led the charge in genomics study. Two papers published in 2003 affirmed a new claim in computational biology, marking the first time multiple eukaryotic genomes were aligned completely. Doing so set a new standard in comparative sequence analysis, with inevitable implications for annotating the human genome and peering into evolutionary history.
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