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By Aileen Constans

RNAi: Five Tips to Better Silencing

Anxious to get going with RNAi? These tips will make your next knockdown a knockout

Thanks to RNA interference it's easier than ever to perform genetic knockouts in cultured cells and live animals. The idea is simple enough: deliver a short interfering RNA (siRNA) for the desired mRNA, wait a few days, and see what happens. In theory, the siRNAs (short double-stranded RNAs homologous to a region of an mRNA) will program the RNA-induced silencing complex to target the desired transcript for degradation.



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