Patch Clamping Unhooked

How to record a single neuron in a moving animal

Direct electrophysiological measurement of neuronal activity in living, breathing animals is challenging. Making such measurements on freely moving, behaving animals has been next to impossible. But recently a research group in The Netherlands and Germany that includes patch-clamp pioneer Bert Sakmann devised a contraption that can take whole-cell recordings from freely moving rats.1 "The potential of this is huge," says Faculty of 1000 member Gerald Zamponi, of the department of physiology and biophysics at the University of Calgary.


	The article you are attempting to read is Premium content which is only available to our online subscribers.

Subscribing to The Scientist is easy and inexpensive.

And you can choose from many options. Try us out with an online day pass starting at only $4.95. Or, get it all with unlimited online access to The Scientist Archive and door-to-door delivery of our monthly print magazine.


	The Scientist also offers site licenses to institutions and organizations. When your librarian adds The Scientist to the library's collection, you can get unlimited online access through your place of work or study. Recommend The Scientist today