Predicting Nucleosome Position

Research suggests a 'code' at work

A group including Jonathan Widom at Northwestern University and Eran Segal of the Weizman Institute used sophisticated computer modeling along with experimental approaches to uncover DNA-encoded rules guiding nucleosome position.1 The verdict: several dinucleotide sequences, because of their inherent bendability, can be used to predict roughly 50% of nucleotide positions. The work, may lead to better prediction of nucleosome binding and may influence such things as transgene design. Bradley Bernstein, a Faculty of 1000 member and assistant professor at Massachusetts General Hospital calls it an "impressive analysis." He adds "The paper identified interesting correlations that are likely to reflect causal relationships."


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