Using an innovative in vitro model of the blood-brain barrier, Dennis Grab of Johns Hopkins University and his colleagues found that Trypanosoma brucei gambiense requires calcium ions and cysteine proteases to migrate across. 1 "This is a big technical and scientific advance," says Paul Roepe of Georgetown University. "We have the beginnings of a real molecular model for how trypanosomes are crossing the blood-brain barrier."
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