As many as half of familial breast cancers can be attributed to germline defects in the notorious breast cancer-associated gene 1 (BRCA1). These defects generally affect the gene product's carboxyl-terminal domain, known as BRCT, a ~100 amino-acid tandem repeat that's found alone or in multiples in a large number of proteins involved in DNA repair and checkpoint control. Yet despite such obvious links with cancer, the exact function of the BRCT domain has remained elusive.
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The Root of BRCA1's Evil
Uncovering the mechanism of cancer-causing defects in a notorious oncogene
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