snoRNAs linked to Prader-Willi Syndrome

Small nucleolar RNAs (snoRNAs) have never before been implicated in alternative splicing. Stefan Stamm and Shivendra Kishore, of the Friedrich-Alexander University Institute for Biochemistry, suggest that HBII-52, a non-coding RNA located on chromosome 15 regulates alternative splicing of the serotonin receptor 2C located on the X chromosome.1 The snoRNA locus is maternally imprinted, and loss of paternal expression results in Prader-Willi Syndrome, a congenital disease characterized by developmental and neurological defects.


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