Stat5a and b have given immunologists mixed messages. Nearly a decade of work pointed to a central role for these transcription factors in T- and B-cell development as well as development of some leukemias, but an N-terminal deletion knockout made in the late 1990s produced relatively mild effects. Recent work on a full-length knockout in mice falls much more in line with what the community had expected.
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A Stat5 flashback
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