The Path to Clinical Protocols :The Scientist [2006-05-01]


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The Path to Clinical Protocols The Edmonton Protocol and its more recent improvements are the product of incremental contributions made during the past 34 years. Paul E. Lacy first extracted islets from the rat pancreas with the enzyme collagenase, and used the islets to reverse diabetes in 1972.1 These tantalizing results in rodents left the distinct impression that islet-replacement therapy was a mere step away from the