A new weapon for resistant bacteria

Methicillin-resistant Staphylococcus aureus (MRSA), a longtime bane of hospitals, thwarts the antibiotic by integrating a mobile genetic element, staphylococcal cassette chromosome mec (SCCmec). More than 10 years ago, Keiichi Hiramatsu's group at Juntendo University in Tokyo started to notice variations of SCCmec, with different combinations of recombinases to transfer the element and one or more resistance genes.

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