Early in the summer of 1991, Valerio Orlando, a postdoc in Renato Paro's lab at the University of Heidelberg, began working on the problem of identifying where proteins bind to chromatin in vivo. Researchers had already figured out how to determine whether a particular protein bound to a specific sequence in vitro. But what about protein occupancy in a living cell?
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Chromatin Immunoprecipitation
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