Re: cancer stem cells. 1,2 Recently we have reported a novel type of cell division involved in the origin and growth of cancers. 3,4 Termed neosis, this type of cell division occurs only in senescent polyploid giant cells and never in normal diploid cells. Up to 10% of tumor cells both in vitro and in vivo are polyploid, and so far there is no explanation of their role in cancer. These resemble senescent cells, which are thought to be part of the tumor suppressor mechanism.












