Scientists once believed that human embryonic stem cells were extraordinarily stable in culture. In 2004, Peter Andrews at the University of Sheffield, UK, and colleagues revealed definitive evidence that lines can develop chromosomal abnormalities.1 Sheffield's group discovered three independent human embryonic stem cell lines that gained chromosome 17q on five independent occasions, after 22 to 60 passages, and occasionally gained chromosome 12. Both are aberrations commonly seen in human embryonal carcinoma cells.
Advertisement
Survey Series
Institutions
For Advertisers
Stem cell woes
|
|||||||||
|
|||||||||
|
