"In science," says Michele Pagano, "unfortunately, there are fashions." In the 1990s, it was fashionable to call mammalian cyclin-dependent kinases (Cdks) essential. Then a series of knockout experiments called those findings into question, leading to a new fashion: that Cdks are not important. Now Philipp Kaldis, of the National Cancer Institute, and colleagues have set the record straight, says Pagano, a Faculty of 1000 member from the New York University Cancer Institute.
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Cdk fashions
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