The idea that caloric restriction slows the aging process for some organisms is nearly as well accepted as the inevitability of aging. In yeast and worms, life extension due to calorie restriction involves the protein deacetylase Sir2. In 2001, Leonard Guarente's lab at the Massachusetts Institute of Technology showed that the histone deacetylase Sir2 needs the forkhead family transcription factor Daf-16 to extend worm life. It was a big clue, says Guarente; someone just needed to put the pieces together in mammals.
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Long Life and Forkhead Deacetylation
Race to understand mammalian longevity marries SIRT1 to FOXO
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