Genomic quirks make Candida albicans a troublesome creature in the lab. Unlike Saccharomyces cerevisiae, which was sequenced in 1996, C. albicans has no known haploid or homozygous form. Using whole genome shotgun sequencing is tricky, because multiple alleles confound standard assembly software. Moreover, the C. albicans genome is full of repeated sequences and recently diverged gene families.
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