The neuromuscular synapse, whereby neurons control muscle, requires the neurotransmitter acetylcholine. Muscle-specific receptor kinase (MuSK) ensures acetylcholine receptors on the muscle are densely clustered. A motif on MuSK critical for its function targets a phosphotyrosine-binding domain, but the identity of the protein bearing this domain had until recently remained elusive.
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Building the synapse
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