To address concerns about microarray reliability, several groups have attempted to evaluate and compare different platforms, but these efforts themselves are open to question. "Each one of those studies was biased one way or another," says Winston Kuo, Harvard researcher and lead author of a recent cross-platform study.1 Kuo points to flaws in earlier efforts, such as different protocols, nonstandard preprocessing, and reliance on probe annotation information.
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Microarrays measure up well
Surprise: study finds good cross-platform comparability
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