Regulatory T cells take the spotlight

It?s a constant nagging problem, how cancers loaded with mutant proteins escape immune response. In 2004, Weiping Zou, now at the University of Michigan School of Medicine in Ann Arbor, and his colleagues showed that human ovarian tumors can recruit regulatory T cells to suppress other T cells.1 They do this by generating large amounts of the chemokine CCL22. Their findings pointed to a significant link between regulatory T-cell levels and patient mortality.


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