Cholesterol's ABCs

Two studies highlight targets for raising HDL.

The message, so odd before, is now standard. Some cholesterol is good, and low levels of high-density lipoprotein (HDL) have repeatedly been implicated in cardiovascular disease. When the ABC1 transporter was found to be associated in the HDL deficiency of patients with Tangier disease,1 scientists began developing models of cholesterol transport to the protective lipoproteins. But, no one had shown the genes involved in transporting cholesterol from arterial macrophages to HDL particles. While high hopes surrounding an HDL-elevating drug were bolstered by one of the Hot Papers featured here, trials in humans were halted prematurely due to higher risk of death in people taking the drug.


	The article you are attempting to read is Premium content which is only available to our online subscribers.

Subscribing to The Scientist is easy and inexpensive.

And you can choose from many options. Try us out with an online day pass starting at only $4.95. Or, get it all with unlimited online access to The Scientist Archive and door-to-door delivery of our monthly print magazine.


	The Scientist also offers site licenses to institutions and organizations. When your librarian adds The Scientist to the library's collection, you can get unlimited online access through your place of work or study. Recommend The Scientist today