The next generation?
This table lists a selection of antipsychotics in the pipeline. For a story on a new class of drugs some are referring to as the "atypical atypicals," click here. For a table of first-generation drugs, click here. For a table of atypicals, click here.
| Bifeprunox | D2 partial, 5-HT1A agonist | III | Solvay | D1, D2, D3, D4 and D5 are the five receptor types for the hormone and neurotransmitter dopamine. 5-HT (5-hydroxytryptamine) refers to the group of receptors for the neurotransmitter serotonin. Each receptor is labeled 1A, 1B, 1D, etc.. Metabotropic glutamate receptors (mGluRs) bind to glutamate, an amino acid and neurotransmitter. The adenosine receptors, for the nucleoside and neurotransmitter adenosine, are labeled with A followed by a number. AChR is the receptor for the neurotransmitter acetylcholine. Glycine is an amino acid and neurotransmitter. It is a co-agonist (as is glutamate) for NMDA receptors. At least 70 different compounds are in various phases of development for the treatment of schizophrenia. These examples demonstrate the range of targets for these drugs and of drug companies producing them. |
| LY2140023 | mGluR2 | II | Eli Lilly | |
| Ocaperidone | D2, 5-HT2A | II | Johnson & Johnson | |
| Dexefaroxan | a2AR, AChR agonist | II | Pierre Fabre | |
| ALX-5407 | Glycine transporter | I | NPS Pharmaceuticals | |
| SSR-181507 | D2, 5-HT1A | I | Sanofi-Aventis | |
| PD-157695 | D2, D3 | preclinical | Pfizer | |
| Organon | Glycine transporter | preclinical | Akzo Nobel | |
| unnamed | mGluR2 | preclinical | Merck & Co. | |
| unnamed | mGluR | preclinical | Taisho |