About two years ago, Valerie Galton, a professor at Dartmouth College, was proceeding along a straightforward line of scientific inquiry. She and her colleagues had developed a knockout mouse deficient in type 2 deiodinase (D2), an enzyme that was thought to be responsible for converting the prohormone thyroxine (T4) to the active hormone, triiodothyronine (T3). The role of type 2 deiodinase in converting thyroid hormone, which Galton helped establish, was considered "conventional wisdom," Galton says. And then the mice were born.
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A knockout strikes out
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