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By Cathy Tran

Searching for Lipid Antigens

NKT-cell triggers lead to therapeutic applications in cancer and asthma.

In the two decades following the discovery of natural killer T (NKT) cells, a major question loomed: Why did these cells exist? The only natural ligand for the CD1d antigen-presenting molecule found on these cells appeared to be α-galactosylceramide (α-Gal-Cer) from marine sponges, hardly an infectious threat.



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