Kwangseog Ahn of Seoul National University led a group that purified protein complexes associated with MHC class I loading and found protein disulfide isomerase (PDI) in the mix of peptides. 1 PDI carries out sulfide-bond oxidation, reduction, and isomerization, assisting in the general folding of proteins with disulfide bonds. So, the link to antigen presentation was "surprising," according to Faculty of 1000 member Laurence Eisenlohr of Thomas Jefferson University in Philadelphia.
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