3-D Neurogenesis: Catch a 3-D glimpse of new neurons in the brain

This spinning 40-micron section of rat hippocampus shows new neurons in the granule cell layer of the dentate gyrus. Mature neurons are labeled in green with NeuN and proliferating cells are labeled in red with BrDU. The video was generated by BrainCells Inc, a La Jolla, Calif. company searching for new antidepressant drugs based on their ability to stimulate neurogenesis in the hippocampus. All antidepressants on the market demonstrate neurogenic properties in animals. BrainCells uses images like this to measures changes in proliferation after a candidate compound has been given to rats.

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Anti-depressants Can Be THE Problem
by Susan

[Comment posted 2007-04-12 14:29:35]

Regarding the quote "searching for new antidepressant drugs based on their ability to stimulate neurogenesis in the hippocampus. All antidepressants on the market demonstrate neurogenic properties in animals." Here's my problem: not all depression is equal. There are many different causes for depression (low blood sugar, infection, Graves disease, SADD, and of course reactions to prescription drugs) and consistently focusing not on the cause of depression but on manipulation and alteration of the hippocampus seems to me to be really bad science. A temporary "fix" is not a good answer to a really serious problem, because who then is going to take the time to discover the root cause of the depression?