Inflammation pathways

To uncover the inflammatory pathways involved in cell injury and death, Kenneth Rock at the University of Massachusetts and colleagues injected necrotic cells into mice deficient in various toll-like receptors and found that neutrophilic inflammatory response was not significantly reduced.1 Using the same strategy in interleukin-1 (IL-1) receptor-deficient mice, along with mice with induced liver damage in situ, they found that the IL-1 pathway was required for the inflammatory response triggered by dead and injured cells.


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