One day in March of 2006, postdoc Mike Lawrence walked into David Liu's laboratory at Harvard University in a slightly anxious mood. He'd been in the lab for nine months with little to show in terms of good results, and he was hoping this day might turn things around. He had taken on a bold new project with his labmate, Kevin Phillips, to test whether changing the charge of surface residues on a protein could reduce its propensity for aggregating.
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