The replication stutter :The Scientist [2008-05-01]


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The replication stutter During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the position of the bead changed as the replication machinery went to work. Every time a lagging strand loop is formed in the DNA , the length of the strand is reduced (middle panel). Upon release