Parsing Out Pluripotency

Investigators identify key players that regulate self-renewal and differentiation in stem cell research.

Pluripotent stem cells can divide into daughter cells that maintain the ability to give rise to all cell types in the body, or they can be triggered to differentiate into a specialized state. In 2006 two groups published Hot Papers that began to tease out the networks of regulators that control the pluripotency-differentiation decision.

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