Going to the Dogs

Elaine Ostrander was a cell biologist at the top of her game. Then she discovered her true passion, and really took off running.

Elaine Ostrander's career got off to a strong start. As a graduate student at the Oregon Health & Sciences University in the 1980s, she published a couple of papers showing how chromatin structure influences gene expression in the tumor virus SV40. As a postdoc at Harvard, Ostrander continued to explore how changes in the conformation of DNA - this time, supercoiling - can regulate transcription; the work appeared in Science in 1990.

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