Cryo-electron microscopy may be the new kid on the structural biology block, but it is a technique on the rise. Although X-ray crystallography remains the dominant technique for solving structures because of its fine atomic resolution, not every protein (especially large complexes) will crystallize, and those that can are sometimes not sufficiently abundant to work with. That's where cryoEM comes in.
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How to troubleshoot sample preparation for cryo-electron microscopy, an up-and-coming structural biology technique.
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