Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.

But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy

But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy

Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.

FEATUREThe Ecology of Tumors Stem cells for brain cancer BY PETER B. DIRKSNeural stem cell biology took off in 1992 when Brent Reynolds and Samuel Weiss, working at the University of Calgary, discovered that culturing mammalian brain cells in serum-free conditions (in EGF and bFGF), yielded clonally derived colonies of undifferentiated neural cells (neurospheres). This culture system demonstrated that cells within these colonies showed cardinal pr

An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.

The following vendors develop and/or market bioluminescence assay kits, products, and instrumentation for a variety of research and clinical laboratory uses. For more information about products, services, and prices, please contact these companies directly. Accurate Chemical and Scientific Corp. 300 Shames Dr. Westbury, N.Y. 11590 (800) 645-6264 - Fax: (516) 997-4948 Analytical Luminescence Laboratory 11760 Sorrento Valley Rd., S

The following vendors develop and/or market bioluminescence assay kits, products, and instrumentation for a variety of research and clinical laboratory uses. For more information about products, services, and prices, please contact these companies directly. Accurate Chemical and Scientific Corp. 300 Shames Dr. Westbury, N.Y. 11590 (800) 645-6264 - Fax: (516) 997-4948 Analytical Luminescence Laboratory 11760 Sorrento Valley Rd., S

The researchers who aided in the development of the ubiquitous green florescent protein as a tool for cell and molecular biology have taken home this year's chemistry prize.

By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo