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» drug resistance and developmental biology

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Contributors

By | April 1, 2015

Meet some of the people featured in the April 2015 issue of The Scientist.

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Control ALT, Delete Cancer

By , , and | April 1, 2015

Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway

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Professional Marksman

By | April 1, 2015

Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.

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Signaling Resistance

By | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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From Many, One

By | April 1, 2015

Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?

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Short, Strong Signals

By | March 25, 2015

Methylation increases both the activity and instability of the signaling protein Notch.

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image: Medical Equipment May Spread Superbug

Medical Equipment May Spread Superbug

By | February 20, 2015

Drug-resistant bacteria have spread in a Los Angeles hospital, perhaps from contaminated endoscopes.

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Anticipating Resistance

By | February 16, 2015

Using computational algorithms and experimental evolution, researchers are predicting antimicrobial-resistance patterns to improve drug design. 

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image: Understanding Antimalarial Drug Resistance

Understanding Antimalarial Drug Resistance

By | January 21, 2015

Researchers identify mutations associated with resistance to the frontline antimalarial drug artemisinin.

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