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» drug resistance

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image: Control ALT, Delete Cancer

Control ALT, Delete Cancer

By , , and | April 1, 2015

Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway

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image: Professional Marksman

Professional Marksman

By | April 1, 2015

Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.

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image: Signaling Resistance

Signaling Resistance

By | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: Medical Equipment May Spread Superbug

Medical Equipment May Spread Superbug

By | February 20, 2015

Drug-resistant bacteria have spread in a Los Angeles hospital, perhaps from contaminated endoscopes.

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image: Anticipating Resistance

Anticipating Resistance

By | February 16, 2015

Using computational algorithms and experimental evolution, researchers are predicting antimicrobial-resistance patterns to improve drug design. 

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image: Understanding Antimalarial Drug Resistance

Understanding Antimalarial Drug Resistance

By | January 21, 2015

Researchers identify mutations associated with resistance to the frontline antimalarial drug artemisinin.

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image: Tracking Tuberculosis Over Time

Tracking Tuberculosis Over Time

By | January 19, 2015

Genomic analysis of a multidrug-resistant lineage pinpoints historical correlations with human events.

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image: Culturing Drug-Resistant Tumors

Culturing Drug-Resistant Tumors

By | November 17, 2014

Improved methods to grow patients’ tumor cells in a dish offer opportunities to find durable therapies.

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image: WHO: TB’s Toll Worse Than Thought

WHO: TB’s Toll Worse Than Thought

By | October 22, 2014

A new report from the World Health Organization finds that tuberculosis has infected hundreds of thousands more people around the world than was estimated a year ago.

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