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tag spinal cord injury culture cell molecular biology developmental biology

Stem Cells Made Waves in Biology and Medicine
Karen Zusi | Oct 1, 2016 | 6 min read
Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.
How Groups of Cells Cooperate to Build Organs and Organisms
Michael Levin | Sep 1, 2020 | 10+ min read
Understanding biology’s software—the rules that enable great plasticity in how cell collectives generate reliable anatomies—is key to advancing tissue engineering and regenerative medicine.
The Neurobiology of Rehabilitation
Ricki Lewis | Jun 29, 2003 | 10+ min read
Courtesy of Eric D. Laywell SPHERES OF PROMISE These neurospheres, clusters of cells in culture derived from the CNS of mice, are stained with antibodies against a neuronal protein (red), and a astrocyte protein (green). They have a nuclear counterstain (blue). The brain and spinal cord were once considered mitotic dead ends, a division of neurons dwindling with toddlerhood, with memory and learning the consequence of synaptic plasticity, not new neurons. But the discovery of neural stem
Lizard on glass tank
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021 | 4 min read
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.
Designing In Vitro Models of the Blood-Brain Barrier
Jyoti Madhusoodanan | Sep 1, 2016 | 7 min read
Choosing the right model, be it 3-D or 2-D, requires wading through varied cell sources, cell types, and cell culture conditions.
Master of the Cell
Judy Lieberman | Apr 1, 2010 | 10+ min read
By Judy Lieberman Master of the Cell RNA interference, with its powerful promise of therapy for many diseases, may also act as a master regulator of most—if not all—cellular processes. RNA silencing. Computer artwork showing a length of RNA (yellow with red rings) bound to an RNA-induced silencing complex (RISC). © Medi-Mation Ltd / Photo Researchers, Inc. ne of the biggest surprises in biology in the past d
New Workhorses of Stem Cell Technology
Ricki Lewis | Jan 21, 2001 | 5 min read
Most media reports on stem cell biology trace the field's origin to two key papers published in 1981.1,2 But Leroy Stevens at the Jackson Laboratory in Bar Harbor, Maine, laid the groundwork in mice from the 1950s through the 1970s, manipulating bizarre growths called embryoid bodies,3 to see what these cells would become. Embryoid bodies formed when cancer cells were transplanted into mouse abdomens. At first they appeared to be a ring of cells enclosing blood, debris, and a few unspecialized c
Debate Over Stem Cell Origins Continues
Ricki Lewis | May 26, 2002 | 7 min read
In science, things are not always as they seem. So it is for transdifferentiation, the apparent interconvertibility of certain specialized cell types and an underlying theme at a symposium on stem cell biology and applications at the recent annual meeting of the American Association for Cancer Research (AACR) in San Francisco. "For the past three years, people have been saying that hematopoietic [blood-forming] stem cells can become just about any tissue, challenging the paradigm that there are
Stem Cell Discoveries Stir Debate
Douglas Steinberg | Nov 12, 2000 | 9 min read
Editor's Note: This is the first of two articles on questions raised by recent stem cell discoveries. The second article, focusing on various organs and the nervous system, will appear in the Nov. 27 issue of The Scientist. Researchers first isolated embryonic stem cells (ESCs) from mouse blastocysts almost 20 years ago, and a paper announcing the discovery of human ESCs emerged in 1998. Adult-derived stem cells (ASCs) have since become the rage in certain quarters of biology, with unexpected--
Neural Tissue Engineering
Aileen Constans | Jun 20, 2004 | 8 min read
GETTING ON YOUR NERVES:Left: courtesy of Anthony Windebank; right courtesy of Christine SchmidtTo facilitate nerve regrowth, tissue engineers employ biodegradable polymer scaffolds. Shown at left, a micrograph of an actual scaffold used to stimulate spinal cord regeneration in rats. Center, a piece of neural tissue grows on an electrically conductive polymer used primarily for peripheral nerve repair (image colored for effect). At right, stained section of a peripheral nerve showing axons in red

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