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tag genetic variation microbiology disease medicine ecology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
T regulatory cell in red sandwiching an antigen presenting cell in blue
Gut Bacteria Help T Cells Heal Muscle: Study
Natalia Mesa, PhD | Mar 14, 2023 | 4 min read
Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.
Variations on a Gene
Amy Francis | Jul 23, 2000 | 10+ min read
Photodisc Although President Bill Clinton surely had something in mind during his 2000 State of the Union address when he asked the nation to "celebrate our diversity," insights into human diversity at the molecular level are promising to speed drug discovery and revolutionize medicine to mark- edly improve human health. Individuals differ at one in 1,000 base pairs, which adds up to a whopping number of human genetic variations when applied to the roughly three billion base pairs of the human g
Landmarks of Human Variations
Maria Anderson | May 9, 2004 | 5 min read
BUILDING BLOCKS:© 2001 AAASAlong a 106-kilobase stretch of human chromosome 21, one study found that 18 haplotype blocks represent a segment of 147 SNPs from 20 individual copies of the chromosome. One block, containing 26 SNPs and spanning 19 kilobases, is detailed at right. The four most common haplotypes, occurring in 16 of the 20 chromosomes sampled, can be identified by two tag SNPs (bottom right). (Adapted from N. Patil, Science, 294:1719–23, 2001)The myriad medical breakthrough
The Scientist Staff | Mar 29, 2024
taming the beast the scientist
Could Tolerating Disease Be Better than Fighting It?
Ashley Yeager | Jun 1, 2019 | 10+ min read
Quieting immune attacks against pathogens and even providing nutrients to the invaders could improve health, according to a new line of research.
Cross section of an organic cell with intracellular organelles
How Intracellular Bacteria Hijack Your Cells
Catherine Offord | Dec 1, 2022 | 10+ min read
Scientists studying pathogens such as Chlamydia, Legionella, and Listeria get a master class in how to control the internal workings of mammalian cells.
3D illustration of a tapeworm infestation in a human intestine
Return of the Worms
Catherine Offord | Dec 1, 2021 | 10+ min read
Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease.

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