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Molecule of DNA forming inside the test tube equipment.3d rendering,conceptual image.
EvaGreen® Dye: The Swiss Army Knife of qPCR
Biotium | Mar 1, 2024 | 7 min read
A green fluorescent dye with a novel DNA binding mechanism improves signal-to-noise in different DNA amplification assays.
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
A scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi. Nanotubes can be seen extending from the E. coli.
What’s the Deal with Bacterial Nanotubes?
Sruthi S. Balakrishnan | Jun 1, 2021 | 10+ min read
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Top Ten Innovations 2011
The Scientist | Jan 1, 2012 | 10+ min read
Our list of the best and brightest products that 2011 had to offer the life scientist
Get the Basics
Gail Dutton | Nov 10, 2002 | 6 min read
Photo: Courtesy of Michelle Lizott Waniewski  DROP AND GIVE ME 20! Attendees at the 2002 NEB workshops labor through basic training. If you've ever been confused by the jargon of molecular biology, you are not alone. With biotechnology in the news day by day, it is easy to forget that for many of us--even for some readers of The Scientist--the tools, techniques, and concepts that undergird much of this research are foreign. To help keep up, some scientists are queuing up to learn the bas
Assessing Differential Gene Expression
Barbara Cunningham | Nov 25, 2001 | 9 min read
As the complete human genome sequence emerges, research shifts from questions of genomics to those of proteomics--determining the function of individual gene products and mapping global gene expression patterns. Gene expression patterns change continually during the course of tissue development and differentiation. The expression of different gene products at any given time within a particular cell defines the cell's characteristics and helps determine how it will react to external stimuli. Alte
Top 10 Innovations 2012
The Scientist | Dec 1, 2012 | 10+ min read
The Scientist’s 5th installment of its annual competition attracted submissions from across the life science spectrum. Here are the best and brightest products of the year.
Building a Better Biosensor
Mike May | May 23, 2004 | 8 min read
A GRADIENT OF PORE SIZES:Courtesy of Michael J. Sailorimparts a rainbow of colors to a porous silicon chip, one of a variety of new biosensor technologies in development around the world. The different colors correspond to different sized pores, ranging from a few nanometers to hundreds of nanometers in diameter. These pores help the device discriminate and detect proteins and other molecules based on their size.One morning in March 1995, the deadly nerve gas sarin wafted through the Tokyo subwa
Prospecting for Gold in Genome Gulch
Amy Adams | Apr 14, 2002 | 9 min read
The human genome is much like the American West of the 1850s: Everyone wants a piece of the pie. Similar to gold prospectors of 150 years ago, biotech and pharmaceutical companies, and even universities, are frantically searching for the nuggets of gold that will help them find the mother lode—a gene whose function is sufficiently marketable to make all of the preliminary research worthwhile. Companies that do strike gold get to introduce new classes of drugs to the market. Others hope to

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