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tag age related macular degeneration disease medicine culture

close-up of a retina showing blood vessels and a damaged spot
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
Katarina Zimmer | Sep 29, 2021 | 5 min read
A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.
Stem Cell Trial for Eye Disease Commences
Jef Akst | Sep 12, 2014 | 2 min read
Researchers at the RIKEN Center for Developmental Biology will treat the first patient in its clinical trial testing an induced pluripotent stem cell-based treatment for age-related macular degeneration.
Women Lose Vision After Stem Cell Treatment
Kerry Grens | Mar 17, 2017 | 2 min read
The adipose-derived cells were injected into the patients’ eyes to treat age-related macular degeneration. 
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Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez, PhD | Feb 8, 2021 | 4 min read
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
Can Destroying Senescent Cells Treat Age-Related Disease?
Katarina Zimmer | Mar 1, 2020 | 10+ min read
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
Image of the Day: Retinal Cell Implant
The Scientist and The Scientist Staff | Apr 17, 2018 | 1 min read
For the first time, a transplant of replacement tissue grown from stem cells has been shown to be feasible for patients with macular degeneration.
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RNA Interference Comes of Age
Diana Kwon | Dec 9, 2020 | 6 min read
The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.
Angiogenesis Research Moves Past Cancer
Jennifer Fisher Wilson | Apr 20, 2003 | 6 min read
Image: Courtesy of Michael Tolentino  Signs of Aging The fundus, opposite the pupil, is shown. This patient has wet, age-related macular degeneration, which occurs when new vessels form to improve the blood supply to oxygen-deprived retinal tissue. The new vessels are delicate and break easily, causing bleeding and damage to surrounding tissue. Blood and lipid in the macula are present. In the past few years, the media have written numerous, hopeful stories of how scientists are stifling
How We Age
The Scientist | Mar 1, 2015 | 10+ min read
From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.

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