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Genetic Reprogramming Restores Vision in Mice: Study
Genetic Reprogramming Restores Vision in Mice: Study
Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.
Genetic Reprogramming Restores Vision in Mice: Study
Genetic Reprogramming Restores Vision in Mice: Study

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

Researchers repaired what is otherwise irreversible damage in the animals’ ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells.

transcription factors, cell & molecular biology

oct4 yamanaka factor oskm ips ipsc induced pluripotent stem cell
Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed
Emma Yasinski | Nov 8, 2019 | 3 min read
Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.
Image of the Day: Switch Gears
Sukanya Charuchandra | Sep 10, 2018 | 1 min read
A gene responsible for the free-moving, primitive nature of fetal cells is expressed in some breast cancer cells in mice and humans.
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018 | 4 min read
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Oct 1, 2017 | 2 min read
Pauses may help cells fine-tune gene expression.
Bacterial Protein Acts as Prion in Yeast and E. coli
Jef Akst | Jan 16, 2017 | 2 min read
Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.
Infographic: How to Build a Synthetic Sensor
Ruth Williams | Nov 30, 2016 | 1 min read
Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.
Adding Padding
Karen Zusi | Nov 1, 2015 | 2 min read
Adipogenesis in mice has alternating genetic requirements throughout the animals’ lives.
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015 | 2 min read
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Enhanced Enhancers
Eric Olson | Nov 1, 2014 | 3 min read
The recent discovery of super-enhancers may offer new drug targets for a range of diseases.
Deaf Mice Hear Again
Dan Cossins | Jan 10, 2013 | 2 min read
A drug applied to the ears of deaf mice has prompted the regrowth of noise-damaged hair cells and resulted in slight improvements in the animals’ hearing.
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