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» transcription factors

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image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: Benefits of Missing MYC

Benefits of Missing MYC

By | January 22, 2015

Mice engineered to have just one copy of the gene Myc live longer, healthier lives than wild-type animals.

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image: Toward Lab-Grown Gametes

Toward Lab-Grown Gametes

By | December 30, 2014

From stem cells, scientists generate early egg- and sperm-like cells in vitro.

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image: Similarities and Differences

Similarities and Differences

By | November 21, 2014

Results from the Mouse ENCODE project point to key divergences in gene regulation architecture compared to humans.

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image: How a Memory Is Made

How a Memory Is Made

By | November 13, 2014

Transcription factor levels dictate which neurons in a network store a memory.

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image: Enhanced Enhancers

Enhanced Enhancers

By | November 1, 2014

The recent discovery of super-enhancers may offer new drug targets for a range of diseases.

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image: Week in Review: June 2–6

Week in Review: June 2–6

By | June 6, 2014

The malnourished microbiome; innate immunity and beige fat; tools for stem cell self-renewal; predicting tomorrow’s PIs; MERS update

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image: Minimal Toolkit for Stem Cell Self-Renewal

Minimal Toolkit for Stem Cell Self-Renewal

By | June 5, 2014

Researchers identify a network of a dozen transcription factors needed to maintain the pluripotent state of mouse embryonic stem cells. 

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image: Researchers Regrow Mouse Thymus

Researchers Regrow Mouse Thymus

By | April 9, 2014

A simple genetic formula coaxes a shrunken mouse thymus to regenerate.  

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image: Deaf Mice Hear Again

Deaf Mice Hear Again

By | January 10, 2013

A drug applied to the ears of deaf mice has prompted the regrowth of noise-damaged hair cells and resulted in slight improvements in the animals’ hearing.

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