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Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.


Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

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image: Adding Padding

Adding Padding

By | November 1, 2015

Adipogenesis in mice has alternating genetic requirements throughout the animals’ lives.


image: Two Papers Pulled for Figure Fraud

Two Papers Pulled for Figure Fraud

By | August 17, 2015

A University of Florida investigation has found the lead author on both studies faked data on stress response in Caenorhabditis elegans.


image: Toggling Between Life and Death

Toggling Between Life and Death

By | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.


image: Benefits of Missing MYC

Benefits of Missing MYC

By | January 22, 2015

Mice engineered to have just one copy of the gene Myc live longer, healthier lives than wild-type animals.

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image: Toward Lab-Grown Gametes

Toward Lab-Grown Gametes

By | December 30, 2014

From stem cells, scientists generate early egg- and sperm-like cells in vitro.


image: Similarities and Differences

Similarities and Differences

By | November 21, 2014

Results from the Mouse ENCODE project point to key divergences in gene regulation architecture compared to humans.


image: How a Memory Is Made

How a Memory Is Made

By | November 13, 2014

Transcription factor levels dictate which neurons in a network store a memory.

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image: Enhanced Enhancers

Enhanced Enhancers

By | November 1, 2014

The recent discovery of super-enhancers may offer new drug targets for a range of diseases.


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