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image: Toward a Nonaddictive Opioid

Toward a Nonaddictive Opioid

By | August 18, 2016

A newly discovered painkiller does not cause respiratory depression or addiction in mice and could be an alternative to frequently abused prescription medicines, researchers report.

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image: Blocking a Stress-Related Gene Relieves Chronic Pain

Blocking a Stress-Related Gene Relieves Chronic Pain

By | February 10, 2016

Inhibiting the activity of a protein involved in the body’s stress response can ease chronic pain in mice.

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image: Week in Review: May 19–23

Week in Review: May 19–23

By | May 23, 2014

Sperm-sex–sensing sows; blocking a pain receptor extends lifespan in mice; stop codons can code for amino acids; exploring the tumor exome

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image: No Pain, Big Gain

No Pain, Big Gain

By | May 22, 2014

Eliminating a pain receptor makes mice live longer and keeps their metabolisms young.

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image: Pain and Progress

Pain and Progress

By | February 1, 2014

Is it possible to make a nonaddictive opioid painkiller?

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image: Centipede Venom Tops Morphine

Centipede Venom Tops Morphine

By | October 1, 2013

The substance targets the same ion channel that's mutated in people who don't feel pain.

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image: Natural Opioids Linked to Chronic Pain

Natural Opioids Linked to Chronic Pain

By | September 19, 2013

The body’s own pain-quelling system may be at the root of chronic pain and symptoms of opioid withdrawal, according to a new study in mice.

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image: From Toxins to Therapeutics

From Toxins to Therapeutics

By | March 19, 2013

Researchers are finding new drugs for chronic pain and autoimmune diseases by modifying animal venom-derived molecules that target the nervous and immune systems.

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image: Pain-Killing Transplants

Pain-Killing Transplants

By | May 23, 2012

Neurons injected into mice help treat chronic pain at its roots, rather than simply alleviating its symptoms.

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image: Metabolites Involved in Chronic Pain

Metabolites Involved in Chronic Pain

By | January 22, 2012

Untargeted metabolic profiling implicates a new suite of metabolites that may be involved in nerve damage-induced pain.

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