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tag immune rejection evolution immunology microbiology genetics genomics

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Top 7 in Immunology
Edyta Zielinska | Aug 2, 2011 | 3 min read
A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
deep-sea anglerfish Melanocetus johnsonii mating parasitic male immunology adaptive immune system cytotoxic t cell antibody
For Mates to Fuse Bodies, Some Anglerfish Have Lost Immune Genes
Katarina Zimmer | Jul 30, 2020 | 6 min read
In most vertebrates, the absence of adaptive immunity would be catastrophic, but in some deep-sea angler fish species, it enables their “wild” and “wacky” mating habits.
mouse in grass microbiome
New Mouse Model Predicts Two Clinical Trial Failures in Humans
Emma Yasinski | Aug 1, 2019 | 4 min read
The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
A Movable Defense
Eugene V. Koonin and Mart Krupovic | Jan 1, 2015 | 10 min read
In the evolutionary arms race between pathogens and hosts, genetic elements known as transposons are regularly recruited as assault weapons for cellular defense.
Mining Bacterial Small Molecules
L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay | Jan 1, 2011 | 10 min read
As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.

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