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tag x ray crystallography genetics genomics neuroscience immunology

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Top 10 Innovations 2013
The Scientist | Dec 1, 2013 | 10+ min read
The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
Bioinformatics, Genomics, and Proteomics
Christopher Smith | Nov 26, 2000 | 10+ min read
Data Mining Software for Genomics, Proteomics and Expression Data (Part 1) Data Mining Software for Genomics, Proteomics and Expression Data (Part 2) High-throughput (HT) sequencing, microarray screening and protein expression profiling technologies drive discovery efforts in today's genomics and proteomics laboratories. These tools allow researchers to generate massive amounts of data, at a rate orders of magnitude greater than scientists ever anticipated. Initiatives to sequence entire genom
Benefiting from the Human Genome
Jennifer Fisher Wilson | Apr 29, 2001 | 5 min read
As one of the leading causes of death in the United States, cancer continues to challenge those working in the field. Despite long-ongoing research, much work remains before cancer is eradicated. Really a large family of diseases, cancer requires diverse methods for treatment and diagnosis that will only come with a better knowledge of the basic biology of the affected systems. Advances in understanding the causes, new techniques for drug discovery, and increased funding of cancer research have
Defeating the Virus
Wayne C. Koff | May 1, 2015 | 10+ min read
Recent discoveries are spurring a renaissance in HIV vaccine research and development.
Immune to Failure
Karen Hopkin | Feb 1, 2013 | 9 min read
With dogged persistence and an unwillingness to entertain defeat, Bruce Beutler discovered a receptor that powers the innate immune response to infections—and earned his share of a Nobel Prize.
Canvassing Protein Complexes
David Secko | Sep 1, 2008 | 4 min read
Two yeast studies begin to identify protein interactions on a genome-wide scale.
Nonradioactive Probes Protect Scientists And Environment
Holly Ahern | Apr 29, 1990 | 5 min read
For many years, geneticists determined the genetic makeup of organisms by examining the physical characteristics of their offspring. But with the discovery of the structure of the DNA double helix, first published by James D. Watson and Francis H.C. Crick in 1953 (Nature, 171:964-7), the science of genetics was forever changed. Scientists soon developed techniques to study the genetic message found in all living cells at the molecular level. One of most important of these methods was the use of

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