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tag genetic manipulation microbiology cell molecular biology culture

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Microscopic image of a live amoeba.
Illuminating Specimens Through Live Cell Imaging
Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read
Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.
Artist’s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Cross section of an organic cell with intracellular organelles
How Intracellular Bacteria Hijack Your Cells
Catherine Offord | Dec 1, 2022 | 10+ min read
Scientists studying pathogens such as Chlamydia, Legionella, and Listeria get a master class in how to control the internal workings of mammalian cells.
Special Report: New Tools Join Old In Microbiological Research
Ricki Lewis | Apr 28, 1991 | 7 min read
Microbiological Research Author: RICKI LEWIS AND HOLLY AHERN, p.24 Microbiology has evolved from ancient art to savvy science. Yesterday's painstaking tasks of culturing and identifying microorganisms have been joined by rapid detection strategies and intricate genetic manipulations. Microbiologists may still streak specimens on agar plates and wait overnight for bacterial colonies to grow, as was done two centuries ago, but today they may also use spectrophotometers or chromatographs. Gas
Researchers target E. coli in the mouse gut
Modifying the Microbiome In Vivo, One Species or Gene at a Time
Niki Spahich, PhD | Feb 16, 2022 | 4 min read
To manipulate the microbiome, researchers engineered a CRISPR delivery system that precisely targets bacteria in the mouse gut.
Combating COVID-19 with Cell-Free Expression
The Scientist | Aug 19, 2020 | 6 min read
Scientists rely on synthetic biology and cell-free expression systems for developing novel approaches to combat the pandemic.
Conceptual image of coronavirus, SARS?Cov?2 infects a human cell
Viruses Target Super-Short Protein Motifs to Disrupt Host Biology
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022 | 10+ min read
Only recently appreciated as critical components of cellular functions, unstructured stretches of amino acids called SLiMs are key to viral-host interactions.

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