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tag bone marrow transplant neuroscience cell molecular biology

Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Molecular Biology
The Scientist Staff | Feb 17, 1991 | 3 min read
R.J. Bandziulis, M.S. Swanson, G. Dreyfuss, "RNA-binding proteins as developmental regulators," Genes and Development, 3, 431-7, April 1989. Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. This amino acid sequence
On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
An illustration of flowers in the shape of the female reproductive tract
Uterus Transplants Hit the Clinic
Jef Akst | Aug 1, 2021 | 10+ min read
With human research trials resulting in dozens of successful deliveries in the US and abroad, doctors move toward offering the surgery clinically, while working to learn all they can about uterine and transplant biology from the still-rare procedure.
Cell Biology
The Scientist Staff | Nov 26, 1995 | 2 min read
Edited by: Karen Young Kreeger F.J. de Sauvage, P.E. Haas, S.D. Spencer, B.E. Malloy, A.L. Gurney, S.A. Spencer, W.C. Darbonne, W.J. Henzel, S.C. Wong, W.-J. Kuang, K.J. Oles, B. Hultgren, L.A. Solberg, Jr., D.V. Goeddel, D.L. Eaton, "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand," Nature, 369:533-8, 1994. (Cited in 102 publications through September 1995) Comments by Dan L. Eaton, Genentech Inc., South San Francisco, Calif. This paper describes the purification,
The MSC: Regeneration Orchestrator
The Scientist Staff | Nov 16, 2020 | 7 min read
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
Scientists Successfully Transplant Human Leukemia Cells into Mice
Diana Kwon | Apr 1, 2017 | 2 min read
While studying the progression of healthy cells into cancerous ones, researchers discover a way to engraft human blood cells into animals.
Brain cell origin solved
Jef Akst | Oct 20, 2010 | 3 min read
Brain macrophages are derived from cells in the embryonic yolk sac, finally solving an ongoing controversy in neuroscience
Human Mesenchymal Stem Cells Differentiate in the Lab
Ricki Lewis | Apr 11, 1999 | 5 min read
While prominent scientists plead with legislators to reconsider their conservative stance on funding human embryonic stem (ES) cell research, a six-year-old company in Baltimore is quietly making the matter moot. In a just-released tour-de-force research report, it is no longer quite so quiet.1 Researchers at Osiris Therapeutics and the Johns Hopkins University School of Medicine coaxed human mesenchymal stem cells (hMSCs) from adults' bone marrow to develop into cartilage, fat, and bone cells
Stem Cell Know-How
Aileen Constans | Sep 1, 2002 | 7 min read
Image: Courtesy of Gwenn-AEL Dnaet ©2002 National Academy of Sciences STEM CELL XENOGRAFT: Identification of human hepatocytes in livers from immune-deficient mice transplanted with human adult hematopoietic stem cells. Photomicrographs of NOD/SCID mouse liver sections from mice transplanted with purified human Lin-CD38-CD34-C1qRp+ cells isolated from umbilical cord blood, harvested 8-10 weeks post-transplant. Tissue sections were stained for HSA (hepatocyte-specific antigen) or c-met

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